The 33-year-old posted a picture on Twitter and added: "Successful medical,Ready for a new challenge!!!"
Eto'o joined the Toffees on a free transfer in August 2014, and has scored four goals in all competitions so far this season.
The Italian club is fourth in Serie A, 13 points behind leaders Juventus.
Sampdoria posted a picture of the striker wearing a club polo shirt on Twitter on Saturday and Eto'o provided his own confirmation on Sunday.
The Cameroon international who scored 25 leagues goal during his two-year spell at rivals Inter Milan.
Eto'o, four-time African Footballer of the Year, scored 12 goals in 35 appearances for Chelsea last season after signing a one-year deal from Russian outfit Anzhi Makhachkala.
...tahdnews: just in time information
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